Coding
Part:BBa_K5238004:Design
Designed by: Yishi Jia Group: iGEM24_NJMU-CHINA (2024-07-10)
Produce niacin for the treatment of depression
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Design Notes
https://www.ncbi.nlm.nih.gov/gene/15552358
Source
References: 1. Chen, M., Wang, X., Wang, Y., Zhao, G., & Zhang, D. (2023). Activation of the HCAR2 Receptor by Niacin Modulates Microglial Response to Amyloid Plaques in Alzheimer's Disease Models. Journal of Neuroinflammation, 21(1), 45-58. 2. Gao, H., Liu, Q., & Yan, Y. (2014). Antidepressant-Induced Reduction of Interferon-γ and Its Implications for Kynurenine Pathway in Major Depressive Disorder. Medical Hypotheses, 83(3), 210-215. 3. Li, L., Zhang, Z., & Dong, J. (2023). Niacin Reverses PHA-Induced Damage in F-98 Cells by Modulating Neuroinflammation Markers and TREM-2/DAP-12 Pathway. Brain Research, 1821(4), 217-229.